Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.

In this study we explored the use of liquid and supercritical carbon dioxide for the creation of a sustained release drug delivery device. An anti-inflammatory (ketoprofen) was dissolved into carbon dioxide at various temperatures (25-55 degreesC) and pressures (65-300 bar) and then exposed to biodegradable braided sutures made of poly(lactide-co-glycolide) copolymers. The effect of temperature, pressure (and hence density), and exposure time were explored on the ability of the sutures to absorb ketoprofen. The diffusion of the drug into the suture was modeled, and diffusion coefficients were calculated. The amount of ketoprofen loaded into the suture increased with pressure and density and decreased with temperature; however, increasing temperature tended to speed up the absorption process.

Main Author: Weinstein, Randy.
Other Authors: Muske, Kenneth., Martin, Sherrie-Ann., Schaeber, Danielle.
Format: Villanova Faculty Authorship
Language: English
Published: 2010
Online Access: http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:179176
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dc_source_str_mv Ind. Eng. Chem. Res. 2010, 49(16), 7281-7286.
author Weinstein, Randy.
author_facet_str_mv Weinstein, Randy.
Muske, Kenneth.
Martin, Sherrie-Ann.
Schaeber, Danielle.
author_or_contributor_facet_str_mv Weinstein, Randy.
Muske, Kenneth.
Martin, Sherrie-Ann.
Schaeber, Danielle.
author_s Weinstein, Randy.
spellingShingle Weinstein, Randy.
Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
author-letter Weinstein, Randy.
author_sort_str Weinstein, Randy.
author2 Muske, Kenneth.
Martin, Sherrie-Ann.
Schaeber, Danielle.
author2Str Muske, Kenneth.
Martin, Sherrie-Ann.
Schaeber, Danielle.
dc_title_str Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
title Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
title_short Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
title_full Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
title_fullStr Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
title_full_unstemmed Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
collection_title_sort_str liquid and supercritical carbon dioxide- assisted implantation of ketoprofen into biodegradable sutures.
title_sort liquid and supercritical carbon dioxide- assisted implantation of ketoprofen into biodegradable sutures.
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description In this study we explored the use of liquid and supercritical carbon dioxide for the creation of a sustained release drug delivery device. An anti-inflammatory (ketoprofen) was dissolved into carbon dioxide at various temperatures (25-55 degreesC) and pressures (65-300 bar) and then exposed to biodegradable braided sutures made of poly(lactide-co-glycolide) copolymers. The effect of temperature, pressure (and hence density), and exposure time were explored on the ability of the sutures to absorb ketoprofen. The diffusion of the drug into the suture was modeled, and diffusion coefficients were calculated. The amount of ketoprofen loaded into the suture increased with pressure and density and decreased with temperature; however, increasing temperature tended to speed up the absorption process.
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dc.title Liquid and supercritical carbon dioxide- Assisted implantation of Ketoprofen into biodegradable sutures.
dc.creator Weinstein, Randy.
Muske, Kenneth.
Martin, Sherrie-Ann.
Schaeber, Danielle.
dc.description In this study we explored the use of liquid and supercritical carbon dioxide for the creation of a sustained release drug delivery device. An anti-inflammatory (ketoprofen) was dissolved into carbon dioxide at various temperatures (25-55 degreesC) and pressures (65-300 bar) and then exposed to biodegradable braided sutures made of poly(lactide-co-glycolide) copolymers. The effect of temperature, pressure (and hence density), and exposure time were explored on the ability of the sutures to absorb ketoprofen. The diffusion of the drug into the suture was modeled, and diffusion coefficients were calculated. The amount of ketoprofen loaded into the suture increased with pressure and density and decreased with temperature; however, increasing temperature tended to speed up the absorption process.
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