Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.

Several lines of evidence have implicated the subthalamic nucleus (STN) in behaviors that require precise temporal control. In order to investigate this possibility further,we trained rats to perform a peak-interval (PI) timing task [S. Roberts, Isolation of an internal clock, J. Exp. Psychol. Anim. B 7 (1981) 242-268] with two durations (10 s and 40 s), and then lesioned the STN by microinjection of ibotenic acid. Lesioned animalswere able to maintain precise temporal control, yetwere unable to inhibit operant responses late in the trial, at times that were unlikely to yield reinforcement. These results indicate the involvement of the STN in impulsive or perseverative response inhibition, but not in temporal processing.

Main Author: Wiener, Martin.
Other Authors: Magaro, Christopher., Matell, Matthew.
Language: English
Published: 2008
Online Access: http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:178169
PID vudl:178169
id vudl:178169
modeltype_str_mv vudl-system:CoreModel
vudl-system:CollectionModel
vudl-system:ResourceCollection
datastream_str_mv DC
PARENT-QUERY
PARENT-LIST-RAW
PARENT-LIST
MEMBER-QUERY
MEMBER-LIST-RAW
LEGACY-METS
LICENSE
AGENTS
PROCESS-MD
THUMBNAIL
STRUCTMAP
RELS-EXT
hierarchytype
sequence_vudl_178165_str 0000000002
has_order_str no
hierarchy_top_id vudl:171664
hierarchy_top_title Villanova Digital Collection
hierarchy_parent_id vudl:178165
hierarchy_parent_title Matell Matthew
hierarchy_sequence 0000000002
hierarchy_first_parent_id_str vudl:178169
hierarchy_sequence_sort_str 0000000002
hierarchy_all_parents_str_mv vudl:171664
vudl:172968
vudl:178165
first_indexed 2014-01-12T00:38:51Z
last_indexed 2014-01-12T00:38:51Z
recordtype vudl
fullrecord <root> <url> http://digital.library.villanova.edu/files/vudl:178169/DC </url> <thumbnail> http://digital.library.villanova.edu/files/vudl:178169/THUMBNAIL </thumbnail> </root>
spelling
institution Villanova University
collection Digital Library
language English
dc_source_str_mv Neuroscience Letters 440, 2008, 176-180.
author Wiener, Martin.
author_s Wiener, Martin.
spellingShingle Wiener, Martin.
Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
author-letter Wiener, Martin.
author_sort_str Wiener, Martin.
author2 Magaro, Christopher.
Matell, Matthew.
author2Str Magaro, Christopher.
Matell, Matthew.
dc_title_str Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title_short Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title_full Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title_fullStr Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title_full_unstemmed Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
collection_title_sort_str accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
title_sort accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
description Several lines of evidence have implicated the subthalamic nucleus (STN) in behaviors that require precise temporal control. In order to investigate this possibility further,we trained rats to perform a peak-interval (PI) timing task [S. Roberts, Isolation of an internal clock, J. Exp. Psychol. Anim. B 7 (1981) 242-268] with two durations (10 s and 40 s), and then lesioned the STN by microinjection of ibotenic acid. Lesioned animalswere able to maintain precise temporal control, yetwere unable to inhibit operant responses late in the trial, at times that were unlikely to yield reinforcement. These results indicate the involvement of the STN in impulsive or perseverative response inhibition, but not in temporal processing.
publishDate 2008
normalized_sort_date 2008-01-01T00:00:00Z
dc_date_str 2008
license_str protected
REPOSITORYNAME FgsRepos
REPOSBASEURL http://hades.library.villanova.edu:8088/fedora
fgs.state Active
fgs.label Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
fgs.ownerId diglibEditor
fgs.createdDate 2013-01-22T07:07:07.240Z
fgs.lastModifiedDate 2013-12-05T17:11:32.760Z
dc.title Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
dc.creator Wiener, Martin.
Magaro, Christopher.
Matell, Matthew.
dc.description Several lines of evidence have implicated the subthalamic nucleus (STN) in behaviors that require precise temporal control. In order to investigate this possibility further,we trained rats to perform a peak-interval (PI) timing task [S. Roberts, Isolation of an internal clock, J. Exp. Psychol. Anim. B 7 (1981) 242-268] with two durations (10 s and 40 s), and then lesioned the STN by microinjection of ibotenic acid. Lesioned animalswere able to maintain precise temporal control, yetwere unable to inhibit operant responses late in the trial, at times that were unlikely to yield reinforcement. These results indicate the involvement of the STN in impulsive or perseverative response inhibition, but not in temporal processing.
dc.date 2008
dc.identifier vudl:178169
dc.source Neuroscience Letters 440, 2008, 176-180.
dc.language en
license.mdRef http://digital.library.villanova.edu/copyright.html
agent.name Falvey Memorial Library, Villanova University
klk
has_thumbnail true
THUMBNAIL_contentDigest_type MD5
THUMBNAIL_contentDigest_digest 203c69e18f4f46c81e9892448d2c07cd
THUMBNAIL_contentLocation_type INTERNAL_ID
THUMBNAIL_contentLocation_ref http://hades.library.villanova.edu:8088/fedora/get/vudl:178169/THUMBNAIL/2013-01-22T07:07:09.313Z
relsext.hasModel info:fedora/vudl-system:CoreModel
info:fedora/vudl-system:CollectionModel
info:fedora/vudl-system:ResourceCollection
relsext.itemID oai:digital.library.villanova.edu:vudl:178169
relsext.isMemberOf info:fedora/vudl:178165
relsext.hasLegacyURL http://digital.library.villanova.edu/Villanova%20Digital%20Collection/Faculty%20Fulltext/Matell%20Matthew/MatellMatthew-bbcbb0fb-67ff-48a1-9f7b-c3f4bbdaf446.xml
relsext.sortOn title
relsext.sequence vudl:178165#2
_version_ 1504192312217960448
score 13.449154
subpages