Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.

Approximately 70% of children treated for cancer are cured, however the treatment often impairs reproductive function. The aim of the present study was to assess ovarian reserve in women with an apparently normal ovarian function, who were cured of cancer in childhood. METHODS: Twenty-one female survivors with regular menstrual cycles and basal FSH <10 IU/l were included. The control group included 21 healthy agematched regularly cycling women. On cycle day 2+/-5, ovarian volume and number of small antral follicles (2+/-5 mm) were evaluated with transvaginal ultrasonography. Repeated sonography, urinary LH testing, and endocrine assessments were performed during the actual cycle. Cycle length was calculated. RESULTS: The female survivors had significantly smaller volume per ovary (4.9 versus 6.8 cm3; P < 0.01), a lower number of small antral follicles per ovary (4.5 versus 8.0; P < 0.01), and lower total number of follicles per ovary (8 versus 11, P < 0.01). Hormonal procles were similar, but the mean cycle length of the female survivors was significantly shorter than in the control group (28.3 versus 31.0 days; P < 0.05). CONCLUSIONS: Childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/l seem to have a diminished ovarian reserve. Consequently, they may have a shortened reproductive span and an early menopause.

Main Author: Larsen, E.
Other Authors: Muller, J., Rechnitzer, C., Schmiegelow, K., Andersen, A.
Language: English
Published: 2003
Online Access: http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:178015
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dc_source_str_mv Human Reproduction 18 (2), Feb 2003, 417-422.
author Larsen, E.
author_s Larsen, E.
spellingShingle Larsen, E.
Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
author-letter Larsen, E.
author_sort_str Larsen, E.
author2 Muller, J.
Rechnitzer, C.
Schmiegelow, K.
Andersen, A.
author2Str Muller, J.
Rechnitzer, C.
Schmiegelow, K.
Andersen, A.
dc_title_str Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
title Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
title_short Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
title_full Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
title_fullStr Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
title_full_unstemmed Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
collection_title_sort_str diminished
title_sort diminished
description Approximately 70% of children treated for cancer are cured, however the treatment often impairs reproductive function. The aim of the present study was to assess ovarian reserve in women with an apparently normal ovarian function, who were cured of cancer in childhood. METHODS: Twenty-one female survivors with regular menstrual cycles and basal FSH <10 IU/l were included. The control group included 21 healthy agematched regularly cycling women. On cycle day 2+/-5, ovarian volume and number of small antral follicles (2+/-5 mm) were evaluated with transvaginal ultrasonography. Repeated sonography, urinary LH testing, and endocrine assessments were performed during the actual cycle. Cycle length was calculated. RESULTS: The female survivors had significantly smaller volume per ovary (4.9 versus 6.8 cm3; P < 0.01), a lower number of small antral follicles per ovary (4.5 versus 8.0; P < 0.01), and lower total number of follicles per ovary (8 versus 11, P < 0.01). Hormonal procles were similar, but the mean cycle length of the female survivors was significantly shorter than in the control group (28.3 versus 31.0 days; P < 0.05). CONCLUSIONS: Childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/l seem to have a diminished ovarian reserve. Consequently, they may have a shortened reproductive span and an early menopause.
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fgs.label Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
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fgs.createdDate 2013-01-22T06:59:20.364Z
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dc.title Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/I.
dc.creator Larsen, E.
Muller, J.
Rechnitzer, C.
Schmiegelow, K.
Andersen, A.
dc.description Approximately 70% of children treated for cancer are cured, however the treatment often impairs reproductive function. The aim of the present study was to assess ovarian reserve in women with an apparently normal ovarian function, who were cured of cancer in childhood. METHODS: Twenty-one female survivors with regular menstrual cycles and basal FSH <10 IU/l were included. The control group included 21 healthy agematched regularly cycling women. On cycle day 2+/-5, ovarian volume and number of small antral follicles (2+/-5 mm) were evaluated with transvaginal ultrasonography. Repeated sonography, urinary LH testing, and endocrine assessments were performed during the actual cycle. Cycle length was calculated. RESULTS: The female survivors had significantly smaller volume per ovary (4.9 versus 6.8 cm3; P < 0.01), a lower number of small antral follicles per ovary (4.5 versus 8.0; P < 0.01), and lower total number of follicles per ovary (8 versus 11, P < 0.01). Hormonal procles were similar, but the mean cycle length of the female survivors was significantly shorter than in the control group (28.3 versus 31.0 days; P < 0.05). CONCLUSIONS: Childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/l seem to have a diminished ovarian reserve. Consequently, they may have a shortened reproductive span and an early menopause.
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dc.source Human Reproduction 18 (2), Feb 2003, 417-422.
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