Effects of repetition and competition on prefrontal activity during word generation.

Neuroimaging studies have revealed an association between word generation and activity in the left inferior frontal gyrus (IFG) that is attentuated with item repetition. The experiment reported here examined the effects of repeated word generation, under conditions in which completion was either decreased or increased, on activity measured during whole-brain echoplanar functional magnetic resonance imaging. Activity in left IFG decreased during repetition conditions that reduced competition but increased during repetition conditions that increased competition; this pattern was contrasted to repetition effects observed in other cortical areas, specifically regions of left temporal cortex. The increase in left IFG activity, which is not predicted by a simple semantic retrieval account of prefrontal function, is consistent with the hypothesis that left IFG subserves the selection of semantic knowledge among competing alternatives.

Main Author: Thompson-Schill, Sharon L.
Other Authors: D'Eposito, Mark., Kan, Irene P.
Format: Villanova Faculty Authorship
Language: English
Published: 1999
Online Access: http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:177563
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dc_source_str_mv Neuron 23, Jul 1999, 513-522.
author Thompson-Schill, Sharon L.
author_facet_str_mv Thompson-Schill, Sharon L.
D'Eposito, Mark.
Kan, Irene P.
author_or_contributor_facet_str_mv Thompson-Schill, Sharon L.
D'Eposito, Mark.
Kan, Irene P.
author_s Thompson-Schill, Sharon L.
spellingShingle Thompson-Schill, Sharon L.
Effects of repetition and competition on prefrontal activity during word generation.
author-letter Thompson-Schill, Sharon L.
author_sort_str Thompson-Schill, Sharon L.
author2 D'Eposito, Mark.
Kan, Irene P.
author2Str D'Eposito, Mark.
Kan, Irene P.
dc_title_str Effects of repetition and competition on prefrontal activity during word generation.
title Effects of repetition and competition on prefrontal activity during word generation.
title_short Effects of repetition and competition on prefrontal activity during word generation.
title_full Effects of repetition and competition on prefrontal activity during word generation.
title_fullStr Effects of repetition and competition on prefrontal activity during word generation.
title_full_unstemmed Effects of repetition and competition on prefrontal activity during word generation.
collection_title_sort_str effects of repetition and competition on prefrontal activity during word generation.
title_sort effects of repetition and competition on prefrontal activity during word generation.
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description Neuroimaging studies have revealed an association between word generation and activity in the left inferior frontal gyrus (IFG) that is attentuated with item repetition. The experiment reported here examined the effects of repeated word generation, under conditions in which completion was either decreased or increased, on activity measured during whole-brain echoplanar functional magnetic resonance imaging. Activity in left IFG decreased during repetition conditions that reduced competition but increased during repetition conditions that increased competition; this pattern was contrasted to repetition effects observed in other cortical areas, specifically regions of left temporal cortex. The increase in left IFG activity, which is not predicted by a simple semantic retrieval account of prefrontal function, is consistent with the hypothesis that left IFG subserves the selection of semantic knowledge among competing alternatives.
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dc.title Effects of repetition and competition on prefrontal activity during word generation.
dc.creator Thompson-Schill, Sharon L.
D'Eposito, Mark.
Kan, Irene P.
dc.description Neuroimaging studies have revealed an association between word generation and activity in the left inferior frontal gyrus (IFG) that is attentuated with item repetition. The experiment reported here examined the effects of repeated word generation, under conditions in which completion was either decreased or increased, on activity measured during whole-brain echoplanar functional magnetic resonance imaging. Activity in left IFG decreased during repetition conditions that reduced competition but increased during repetition conditions that increased competition; this pattern was contrasted to repetition effects observed in other cortical areas, specifically regions of left temporal cortex. The increase in left IFG activity, which is not predicted by a simple semantic retrieval account of prefrontal function, is consistent with the hypothesis that left IFG subserves the selection of semantic knowledge among competing alternatives.
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