The aminosterol antibiotic squalamine permeabilizes large unilamellar phospholipid vesicles.

The ability of the shark antimicrobial aminosterol squalamine to induce the leakage of polar fluorescent dyes from large unilamellar phospholipid vesicles (LUVs) has been measured. Micromolar squalamine causes leakage of carboxyfluorescein (CF) from vesicles prepared from the anionic phospholipids p...

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Bibliographic Details
Main Authors: Selinsky, Barry., Zhou, Zhao., Fojtik, Kristin., Jones, Stephen., Dollahon, Norman., Shinnar, Ann.
Format: Villanova Faculty Authorship
Language:English
Published: 1997
Online Access:http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:175908