Staff View: Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.

Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.

Bibliographic Details
Main Authors:	Reed, Jennifer M., Branigan, Patrick J., Bamezai, Anil.
Format:	Villanova Faculty Authorship
Language:	English
Published:	2008
Online Access:	http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:174019

Main Authors:

Reed, Jennifer M., Branigan, Patrick J., Bamezai, Anil.

Format:

Villanova Faculty Authorship

Language:

English

Published:

2008

Online Access:

http://ezproxy.villanova.edu/login?url=https://digital.library.villanova.edu/Item/vudl:174019

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spelling	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells. Reed, Jennifer M. Branigan, Patrick J. Bamezai, Anil. Interferon-γ (IFN-γ) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-γ is produced by natural killer and natural killer T cells. Although the effects of this cytokine on antigen presenting cells and other cell types are known, its direct role on CD4+ T cells remains unclear. We demonstrate that CD4+ T cells exposed to IFN-γ proliferate more vigorously than the controls in response to signals through the antigen receptor. The increased proliferation of IFN-γ-treated CD4+ T cells is not due to enhanced signaling through the antigen receptor, but is accounted for by their increased survival. Our data suggest that enhanced survival of IFN-γ-treated CD4+ T cells is independent of signal transducer and activator of transcription 1 (STAT 1), a transcription factor that controls the expression of a variety of IFN-γ-targeted genes. In addition, we demonstrate that independent of STAT1, IFN-γ treatment increases the expression of double-stranded RNA-dependent protein kinase, a kinase involved in regulating protein synthesis. Taken together, our findings suggest a direct role of IFN-γ on unstimulated CD4+ T cells that is likely to enhance the advent of adaptive immunity by augmenting their survival during the initiation of the immune response. 2008 Villanova Faculty Authorship vudl:174019 Journal of Interferon & Cytokine Research 28, 2008, 611-622. en
dc.title_txt_mv	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
dc.creator_txt_mv	Reed, Jennifer M. Branigan, Patrick J. Bamezai, Anil.
dc.description_txt_mv	Interferon-γ (IFN-γ) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-γ is produced by natural killer and natural killer T cells. Although the effects of this cytokine on antigen presenting cells and other cell types are known, its direct role on CD4+ T cells remains unclear. We demonstrate that CD4+ T cells exposed to IFN-γ proliferate more vigorously than the controls in response to signals through the antigen receptor. The increased proliferation of IFN-γ-treated CD4+ T cells is not due to enhanced signaling through the antigen receptor, but is accounted for by their increased survival. Our data suggest that enhanced survival of IFN-γ-treated CD4+ T cells is independent of signal transducer and activator of transcription 1 (STAT 1), a transcription factor that controls the expression of a variety of IFN-γ-targeted genes. In addition, we demonstrate that independent of STAT1, IFN-γ treatment increases the expression of double-stranded RNA-dependent protein kinase, a kinase involved in regulating protein synthesis. Taken together, our findings suggest a direct role of IFN-γ on unstimulated CD4+ T cells that is likely to enhance the advent of adaptive immunity by augmenting their survival during the initiation of the immune response.
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author	Reed, Jennifer M. Branigan, Patrick J. Bamezai, Anil.
spellingShingle	Reed, Jennifer M. Branigan, Patrick J. Bamezai, Anil. Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
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description	Interferon-γ (IFN-γ) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-γ is produced by natural killer and natural killer T cells. Although the effects of this cytokine on antigen presenting cells and other cell types are known, its direct role on CD4+ T cells remains unclear. We demonstrate that CD4+ T cells exposed to IFN-γ proliferate more vigorously than the controls in response to signals through the antigen receptor. The increased proliferation of IFN-γ-treated CD4+ T cells is not due to enhanced signaling through the antigen receptor, but is accounted for by their increased survival. Our data suggest that enhanced survival of IFN-γ-treated CD4+ T cells is independent of signal transducer and activator of transcription 1 (STAT 1), a transcription factor that controls the expression of a variety of IFN-γ-targeted genes. In addition, we demonstrate that independent of STAT1, IFN-γ treatment increases the expression of double-stranded RNA-dependent protein kinase, a kinase involved in regulating protein synthesis. Taken together, our findings suggest a direct role of IFN-γ on unstimulated CD4+ T cells that is likely to enhance the advent of adaptive immunity by augmenting their survival during the initiation of the immune response.
title	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
title_full	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
title_fullStr	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
title_full_unstemmed	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
title_short	Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
title_sort	interferon gamma enhances clonal expansion and survival of cd4+ t cells.
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Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.
Reed, Jennifer M.
Branigan, Patrick J.
Bamezai, Anil.
Interferon-γ (IFN-γ) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-γ is produced by natural killer and natural killer T cells. Although the effects of this cytokine on antigen presenting cells and other cell types are known, its direct role on CD4+ T cells remains unclear. We demonstrate that CD4+ T cells exposed to IFN-γ proliferate more vigorously than the controls in response to signals through the antigen receptor. The increased proliferation of IFN-γ-treated CD4+ T cells is not due to enhanced signaling through the antigen receptor, but is accounted for by their increased survival. Our data suggest that enhanced survival of IFN-γ-treated CD4+ T cells is independent of signal transducer and activator of transcription 1 (STAT 1), a transcription factor that controls the expression of a variety of IFN-γ-targeted genes. In addition, we demonstrate that independent of STAT1, IFN-γ treatment increases the expression of double-stranded RNA-dependent protein kinase, a kinase involved in regulating protein synthesis. Taken together, our findings suggest a direct role of IFN-γ on unstimulated CD4+ T cells that is likely to enhance the advent of adaptive immunity by augmenting their survival during the initiation of the immune response.
2008
Villanova Faculty Authorship
vudl:174019
Journal of Interferon & Cytokine Research 28, 2008, 611-622.
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Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.

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Reed, Jennifer M.
Branigan, Patrick J.
Bamezai, Anil.

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Interferon-γ (IFN-γ) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-γ is produced by natural killer and natural killer T cells. Although the effects of this cytokine on antigen presenting cells and other cell types are known, its direct role on CD4+ T cells remains unclear. We demonstrate that CD4+ T cells exposed to IFN-γ proliferate more vigorously than the controls in response to signals through the antigen receptor. The increased proliferation of IFN-γ-treated CD4+ T cells is not due to enhanced signaling through the antigen receptor, but is accounted for by their increased survival. Our data suggest that enhanced survival of IFN-γ-treated CD4+ T cells is independent of signal transducer and activator of transcription 1 (STAT 1), a transcription factor that controls the expression of a variety of IFN-γ-targeted genes. In addition, we demonstrate that independent of STAT1, IFN-γ treatment increases the expression of double-stranded RNA-dependent protein kinase, a kinase involved in regulating protein synthesis. Taken together, our findings suggest a direct role of IFN-γ on unstimulated CD4+ T cells that is likely to enhance the advent of adaptive immunity by augmenting their survival during the initiation of the immune response.

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Branigan, Patrick J.
Bamezai, Anil.

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Branigan, Patrick J.
Bamezai, Anil.
Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.

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Interferon Gamma Enhances Clonal Expansion and Survival of CD4+ T Cells.

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